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A woman with poorly managed hypothyroidism may have elevated prolactin purely as a downstream consequence

doi: 10.1016/j.tplants.2008.10.007

26 THE CONCEPT OF CO-AGONISTS IN GLUCOSE-LOWERING AND WEIGHT LOSS TREATMENTS In the search for the next step beyond GLP-1 RAs as treatment for T2DM and/or obesity, the combination of GLP1 with other gut hormones (including glucose-dependent insulinotropic polypeptide [GIP], amylin and glucagon) as dual or triple agonists has been trialled to complement and enhance further the metabolic benefits of GLP-1 by addressing multiple different mechanisms of action